WTA Player Stats - Laura Siegemund
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| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 23 - Apr. 4 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Christina McHale | Win | 6-3, 7-5 |
| Second Round | Victoria Azarenka | Loss | Retired |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Mar. 7 - Mar. 13 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Anastasia Potapova | Loss | 3-6, 2-6 |
| Qatar Total Open 2021 | ||
| Surface: Hard | Date: Mar. 1 - Mar. 6 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Elena Rybakina | Win | 7-6 (9-7), 7-6 (7-5) |
| Second Round | Victoria Azarenka | Loss | 4-6, 2-6 |
| Adelaide International | ||
| Surface: Hard | Date: Feb. 22 - Feb. 27 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Yulia Putintseva | Loss | 4-6, 4-6 |
| Australian Open | ||
| Surface: Hard | Date: Feb. 8 - Feb. 21 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Serena Williams | Loss | 1-6, 1-6 |
| Gippsland Trophy | ||
| Surface: Hard | Date: Jan. 31 - Feb. 6 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Monica Niculescu | Win | 7-5, 6-4 |
| Second Round | Destanee Aiava | Win | 6-2, 6-2 |
| Third Round | Simona Halep | Loss | 2-6, 4-6 |
| Abu Dhabi WTA Women's Tennis Open | ||
| Surface: Hard | Date: Jan. 6 - Jan. 13 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Kirsten Flipkens | Loss | 7-5, 5-7, 4-6 |
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