WTA Player Stats - Laura Siegemund
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| Wimbledon | ||
| Surface: Grass | Date: Jun. 28 - Jul. 11 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Ekaterina Alexandrova | Loss | 1-6, 3-6 |
| Bad Homburg Open | ||
| Surface: Grass | Date: Jun. 20 - Jun. 26 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Riya Bhatia | Win | 2-6, 7-6 (7-2), 6-1 |
| Second Round | Tamara Korpatsch | Win | 6-2, 6-2 |
| Quarterfinals | Katerina Siniakova | Loss | 5-7, 4-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 30 - Jun. 13 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Caroline Garcia | Loss | 3-6, 1-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 9 - May 16 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Nadia Podoroska | Loss | 6-2, 6-7 (3-7), 1-6 |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 29 - May 9 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Kateryna Kozlova | Win | 6-4, 6-2 |
| Second Round | Iga Swiatek | Loss | 3-6, 3-6 |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 19 - Apr. 25 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Mona Barthel | Win | 6-4, 3-6, 6-1 |
| Second Round | Ashleigh Barty | Loss | 0-6, 5-7 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 23 - Apr. 4 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Christina McHale | Win | 6-3, 7-5 |
| Second Round | Victoria Azarenka | Loss | Retired |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Mar. 7 - Mar. 13 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Anastasia Potapova | Loss | 3-6, 2-6 |
| Qatar Total Open 2021 | ||
| Surface: Hard | Date: Mar. 1 - Mar. 6 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Elena Rybakina | Win | 7-6 (9-7), 7-6 (7-5) |
| Second Round | Victoria Azarenka | Loss | 4-6, 2-6 |
| Adelaide International | ||
| Surface: Hard | Date: Feb. 22 - Feb. 27 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Yulia Putintseva | Loss | 4-6, 4-6 |
| Australian Open | ||
| Surface: Hard | Date: Feb. 8 - Feb. 21 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Serena Williams | Loss | 1-6, 1-6 |
| Gippsland Trophy | ||
| Surface: Hard | Date: Jan. 31 - Feb. 6 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Monica Niculescu | Win | 7-5, 6-4 |
| Second Round | Destanee Aiava | Win | 6-2, 6-2 |
| Third Round | Simona Halep | Loss | 2-6, 4-6 |
| Abu Dhabi WTA Women's Tennis Open | ||
| Surface: Hard | Date: Jan. 6 - Jan. 13 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Kirsten Flipkens | Loss | 7-5, 5-7, 4-6 |
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